Plenary and Keynote Speakers
Professor Detlef Lohse, University of Twente
Title: Physicochemical Hydrodynamics of Droplets out of Equilibrium
Abstract: Please click here.
Bio: Professor Lohse graduated from the University of Bonn in 1989 with a degree in Physics, and completed his PhD at the University of Marburg in 1992.
He served as a postdoctoral research fellow at the University of Chicago from 1993 to 1995, and became chair of Physics of Fluids at the University of Twente in 1998.
His present work includes turbulence and two-phase flows, granular flow, micro- and nanofluidics, and the biomedical application of bubbles.
Professor Lohse was a recipient of the 2019 Max Planck Medal, 2018 Balzan Prize, 2017 Fluid Dynamics Prize, 2012 Batchelor Prize, 2005 Spinoza Prize for his work on turbulence, thermal convection, multiphase flow, microfluidics, sonoluminescence, and was awarded a knighthood in the Order of the Netherlands Lion in 2010. He is also a member of the Royal Netherlands Academy of Arts and Sciences since 2005, a member of the National Academy of Engineering since 2017, and a Fellow of the American Physical Society.
Professor Lydia Bourouiba, MIT
Title: Unsteady fluid fragmentation
Abstract: Despite the complexity and diversity of modes of unsteady fluid fragmentation into secondary droplets, universality across geometry and fluid systems emerges. We discuss the role of unsteadiness in shaping a ubiquitous, yet neglected class of fluid fragmentation problems based on recent joint experimental and theoretical investigations. In particular, we reveal how unsteadiness and multi-scale dynamics couple to select both the sizes and speeds of secondary droplets generated.
Bio: Prof. Lydia Bourouiba is Associate Professor at the Massachusetts Institute of Technology, where she directs the Fluid Dynamics of Disease Transmission Laboratory. Her research specializes in developing and joining advanced fluid dynamics experiments at various scales and applied mathematics to elucidate the fundamentals of fluid fragmentation, with particular interest in the resulting mixing and transport of particles, contaminants, and organisms relevant for health, where drops, multiphase, and complex flows are at the core. More on her recent work can be found at http://lbourouiba.mit.edu/
Professor John Thome, EPFL
(with Dr Chiara Falsetti, Oxford)
Title: Modelling of Flow Boiling in Microscale Pin Fin Arrays
Abstract: This study presents the development and results of a new flow pattern-based prediction method for two-phase boiling heat transfer in a micro-pin fin evaporator. The heat transfer mechanisms associated with slug flow and annular flow regimes are inferred by updating the widely used three-zone model of Thome et al. (2004), Dupont et al. (2004) and the algebraic turbulence model of Cioncolini and Thome (2011), respectively. These two models are linearly combined by utilizing a smoothing function acting on a buffer zone centered in the slug-to-annular flow transition region, which is here obtained by means of a new method based on flow visualization analysis and time-strip technique of the available experimental data. The model is compared to a wide experimental database (7219 points), which covers three refrigerants, R134a, R236fa and R1234ze(E), three outlet saturation temperatures (25, 30, and 35 _C), mass fluxes varying from 500 to 2000 kg m_2 s_1 and heat fluxes from 20 to 44Wcm_2. The new flow pattern-based model predicts 72% of the experimental databank within the _30%, with a Mean Absolute Error of 23:4%.
Bio: John R. Thome is Professor of Heat and Mass Transfer at the Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland since 1998, where his primary interests of research are two-phase flow and heat transfer, covering both macro-scale and micro-scale heat transfer and enhanced heat transfer. He directs the Laboratory of Heat and Mass Transfer (LTCM) at the EPFL with a research staff of about 18-20 and is also Director of the Doctoral School in Energy. He received his Ph.D. at Oxford University, England in 1978. He is the author of four books: Enhanced Boiling Heat Transfer (1990), Convective Boiling and Condensation, 3rd Edition (1994), Wolverine Engineering Databook III (2004) and Nucleate Boiling on Micro-Structured Surfaces (2008). He received the ASME Heat Transfer Division's Best Paper Award in 1998 for a 3-part paper on two-phase flow and flow boiling heat transfer published in the Journal of Heat Transfer. He has received the J&E Hall Gold Medal from the U.K. Institute of Refrigeration in February, 2008 for his extensive research contributions on refrigeration heat transfer and more recently the 2010 ASME Heat Transfer Memorial Award. He has published widely on the fundamental aspects of microscale and macroscale two-phase flow and heat transfer and on enhanced boiling and condensation heat transfer.
Professor Douglas H. Kelley, University of Rochester
Title: Microscale flows removing waste from the brain: Drivers, characteristics, and mysteries
Abstract:The human brain accounts for just 2% of the body's mass but metabolizes 25% of its calories, producing significant metabolic waste. However, waste buildup links to neurodegenerative diseases like Alzheimer's and Parkinson's. The brain is thought to remove waste via the recently-identified glymphatic system, a combination of spaces and channels through which cerebrospinal fluid could flow to sweep away toxins like amyloid-beta. With an interdisciplinary group of neuroscientists and physical scientists, I study the fluid physics of the glymphatic system: Where does fluid flow, and how fast? What drives flow? What characteristics of the system enable essential functions? How can we improve waste removal? Can we use glymphatic flow to deliver drugs? The team combines physics tools like particle tracking and newly-invented front tracking with biological tools like two-photon imaging through cranial windows in order to address these questions with in vivo flow measurements. I will talk about recent results showing that glymphatic flow proceeds along vessels with near-optimal shapes, pulses with the heart, is driven by artery walls, can be manipulated by changing the wall motion, and is the dominant source of swelling soon after ischemic stroke.
Bio: Douglas H. Kelley is an Associate Professor of Mechanical Engineering and earned a PhD in physics from the University of Maryland. He held postdoctoral appointments at Yale University (in mechanical engineering) and Massachusetts Institute of Technology (in materials science and engineering). Previously he earned an MS from Auburn University and a BS from Virginia Tech. Doug is a member of the American Physical Society, ASME, and AAAS.
Professor Koji Takahashi, Kyushu University
Title: Gas molecules at solid-liquid interfaces
The physics of solid-liquid interface is very fascinating where many fundamental phenomena are left unsettled in a wide range of science and technology fields. The talk will provide new insight to the gas molecules just on the interface experimentally studied by using AFM and TEM. For example, generation and growth of interfacial nanobubbles are explained with the consideration of unique gas phases thinner than 5nm. Technical tips are also introduced for successful observation of water at the nanoscale.
Koji Takahashi received his Doctor of Engineering from the University of Tokyo, Japan in 1992. He is currently a Professor in Aeronautics and Astronautics at Kyushu University and WPI Professor at the International Institute for Carbon-Neutral Energy Research, Japan. His major interests are micro/nanoscale heat transfer and thermal property of nanomaterials. He has published more than 150 archival Journal articles and peer-reviewed conference papers and was awarded the Scientific Award of the Heat Transfer Society of Japan in 2008 and 2020, JSME Medal for Outstanding Paper in 2012, and Thermal Engineering Achievement Award of JSME in 2016.
Professor James E. Moore Jr, Imperial College London
Title: The Roles of Fluid Flow in Immune System Function
One of the life-sustaining roles for the lymphatic system is to gather information on infections so that the body’s immune system can develop appropriate defenses. Fluid mechanics plays crucial roles at multiple scales in the collection of interstitial fluid and antigenic information into lymph nodes for further processing. Lymph nodes are immune information collection and transfer junctions, where immune cells are housed in sufficient numbers and varieties to develop effective immune responses. The type of information delivered to the lymph nodes includes free antigen, antigen presenting cells, cytokines and other immune cells/signals. Once inside the node, the information must be relayed to the correct region, where carefully orchestrated processes in specific nodal compartments result in the production of antigen-reactive cells and/or antibodies. These processes also rely on fluid flow and cytokine transport. Adaptive immunity thus requires an exquisitely complex combination of active pumping, cell/antigen transport, and biological signaling between multiple cell types.
Employing a combination of in vivo and excised vessel experiments, along with multiscale lumped parameter modeling, we have analyzed the effects of local pressure conditions and vasoactive substances on vessel pumping dynamics. Pumping dynamics of afferent vessels, and therefore the delivery of immune information to lymph nodes, are strongly affected by variations in local pressure, including the external pressure and vasoactive effects of vaccinations. We have also performed a series of microfluidic chamber experiments and computational simulations of flow patterns within lymph nodes. Lymph flow helps to shape concentration gradients of chemokines that provide guiding cues for antigen presenting cells to interact with B and T cells. A better understanding of these transport phenomena could lead to more relevant criteria for designing methods to modulate the immune system effectively for health benefit, including vaccines.
Prof. Moore received his Ph.D. from the Georgia Institute of Technology, followed by postdoctoral training at the Swiss Institute of Technology at Lausanne. Prior to coming to Imperial College, he was the Carolyn S. and Tommie E. Lohman ’59 Professor of Biomedical Engineering at Texas A&M University. In January 2013, he joined Imperial College as the Bagrit and Royal Academy of Engineering Chair in Medical Device Design in the Department of Bioengineering. Prof. Moore’s research interests include Cardiovascular Biomechanics, Stents, Implantable Devices, Atherosclerosis, and the Lymphatic System. His research focuses on the role of biomechanics in the formation and treatment of diseases such as atherosclerosis and cancer. His cardiovascular biomechanics work resulted in the development of two novel stent designs aimed at optimizing post-implant biomechanics for the prevention of restenosis, as well as new testing devices for implants that employ more physiologic mechanical forces. His research on lymphatic system biomechanics has provided unprecedented insight into the pumping characteristics of the system and the transport of nitric oxide, antigens, and chemokines in lymphatic tissues. He is currently developing two technologies for preventing and resolving secondary lymphedema, which typically forms subsequent to cancer surgery. Along with his funding from government, charity, and industry sources, Prof. Moore has received multiple patents for medical devices and testing equipment. Prof. Moore has also co-founded three startup companies. He is a Fellow of ASME, AIMBE and IMECHE.